When discussing male reproductive aging, people typically focus on three metrics: testosterone levels, sperm concentration, и DNA fragmentation rate. However, a review article published in February 2026 in the World
Introduction In the functional nutrition industry, the question is no longer "How much active ingredient is included?" but rather "How much can the body actually utilize?" For a highly fragile
Friends working in the NAD⁺ и brain health industries have likely asked themselves the same question: NR (Nicotinamide Riboside) is widely recognized as one of the most effective NAD⁺ precursors. From h
Liposomal NAD⁺ Delivers Up to 30% Greater Transdermal Absorption For years, NAD⁺ has been one of the most talked-about anti-aging ingredients in the skincare industry. Countless brиs have invested heavily in developin
През последните години NAD+ несъмнено се превърна в една от най-горещите молекули в областта на анти-стареенето и здравословната дълголетие. От научни лаборатории до потребителски пазари, дискусиите около нея никога не са спирали.
Aging is being redefined. In 2022, the World Health Organization (WHO) introduced a dedicated code for "aging-related" conditions for the fIRst time in the 11th Revision of the International Classification of
In the long journey against type 2 diabetes, scientists continue to explore new therapeutic strategies. Recently, a study published in the International Journal of Molecular Sciences revealed potential new mechanism
In annual pet health checkups, NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a sensitive marker of myocardial stress. When its levels exceed the normal range, it usually indicates that the heart is under
When it comes to anti-aging, boosting energy, и maintaining vascular health, many people have heard of a specific term—NMN (Nicotinamide Mononucleotide). In recent years, it has garnered significant attention due
The global population is aging at an unprecedented pace. The World Health Organization (WHO) predicts that by 2050, the global population aged 60 и older will exceed 2.1 billion—meaning 1 in every 5 people will b
Recently, NMNH (Reduced $\beta$-Nicotinamide Mononucleotide) has once again sparked widespread attention in the anti-aging field due to newly released human clinical trials. Although both are precursor molecules of
В водещата област на изследванията срещу стареене "семейството коензими" се превърна в гореща тема в индустрията. NMN, предшественик на NAD+, някога завладя света благодарение на подкрепата от високопрофилни филми
Long COVID lingers like a persistent shadow, leaving hundreds of millions worldwide struggling with brain fog, fatigue, и insomnia. In November 2025, a team from Harvard Medical School published a 24-week double-blind
В бързия ритъм на съвременен живот умората и безсънието сякаш са станали "чести гости" за много хора. Изправени пред тези проблеми, учените откриха, че те са свързани с изчерпването на "ене"
Същността на стареенето е клетъчна "енергийна криза". Докато учените навлизат по-дълбоко в изследванията на NAD+, този коензим постепенно се превръща в основна цел в областта на анти-стареенето. Изследванията показват, че директор
Загуба на енергия, задух при изкачване по стълби, колебания в кръвната захар след хранене и все по-трудно сваляне на мазнини... Тези телесни усещания за "остаряване" всъщност са страстни
In April 2026, China officially released its fIRst national consensus document: the Chinese Expert Consensus on the Role и Clinical Application of NAD⁺ in Aging-Related Diseases (2026 Edition). Led by the Chinese Me
High blood pressure, often called the “silent killer,” is the most important modifiable risk factor for cardiovascular disease. Yet many people face the same frustration: even when taking antihypertensive med
С застаряването на световното население, дегенеративните промени в мускулно-скелетната система (като остеоартрит, остеопороза и саркопения) сериозно влияят на качеството на живот на възрастните хора. Клатещи се крака при ходене, ди
When discussing liver health, one fundamental question arises: how can we effectively support this “biochemical factory of the human body” in its complex repaIR processes when faced with metabolic stress, fat
In the field of anti-aging, NMN (nicotinamide mononucleotide) has long been a highly regarded “star molecule.” As a dIRect precursor of NAD⁺, it shows great potential in energy metabolism, DNA repaIR, и ant
In recent years, NAD+ (nicotinamide adenine dinucleotide) has become a highly sought-after “star molecule” in the health и anti-aging field due to its tremendous potential. The most common supplements on th
For a long time, NAD (nicotinamide adenine dinucleotide) has been almost a “stиard configuration” in IVD testing. From dehydrogenase reactions to the precise readout of endpoint signals, detection pathways
Parkinson’s disease is not merely about tremors. More concerning is that most patients gradually develop cognitive impaIRment, which may eventually progress to dementia. Unfortunately, traditional medications can o
How remarkable is the liver’s regenerative ability? Even when two-thIRds of a healthy liver is surgically removed, it can restore its original size within just a few weeks. However, under conditions such as disease
През последните години NAD+ често се появява в центъра на популярни теми като здраве, анти-стареене и когнитивно подобрение. Изглежда, че е изскочил от лабораторията в ежедневието, превръщайки се в нов фаворит
In the vast world of raw materials, some names seem to rise to prominence overnight. Yet in reality, theIR success is never accidental. NRHM (Nicotinamide Riboside Hydrogen Malate) is one such name—frequently appe
Може ли една молекула в човешкото тяло да се превърне в ключов двигател на здравето на сърцето? Никотинамид аденин динуклеотид (NAD+) бързо се оформя като основен фокус на научните изследвания. Като основен участник в енергийните метаболи
В изследванията на анти-стареещите механизми никотинамид рибозид (NR), предшественик на NAD⁺, постепенно привлича все по-голямо внимание от научните институции. През септември 2023 г. национален патент за изобретение, свързан с
Когато говорим за здраве, червата често са в центъра на дискусията. Той не само отговаря за храносмилането и усвояването на хранителни вещества, но и представлява най-големия имунен орган в човешкото тяло. В последно време да
In the fields of anti-aging, cellular energy, и biotechnology, the term “NAD⁺” has almost been elevated to a mythical status. Yet, when people come across NAD⁺-related products, many still find themsel
Age is typically defined as the length of time since bIRth. However, a person’s true physical condition и degree of aging are better reflected by theIR biological age rather than the number of years they have liv
С нарастването на осведомеността за здравословното хранене, натурални подсладители с нулеви калории се превърнаха в основен фокус на вниманието на потребителите. През юни 2025 г. изследване беше публикувано в международното списание Food Chemistry: X систематично
While we are deeply engaged in exploring anti-aging solutions for humans, our furry companions at home are quietly facing health challenges brought on by aging—reduced energy levels, dull coats, и a slower metabo
Have you ever experienced moments like these: walking into a room и forgetting why you went there, struggling to recall a familiar name, or suffering from persistent insomnia after staying up late—followed by day
In today’s global wave of health awareness, “sugar reduction” has become a widely accepted trend. Steviol glycosides, as natural zero-calorie sweeteners, have already entered households worldwide. Howev
Recently, a study published on bioRxiv revealed the metabolic secrets behind the remarkable longevity of centenarians. Led by Boston University, the research conducted metabolomic analyses on 213 participants—
В съвременното търсене на здраве и дълголетие, научният фокус се е изместил от макронутриентите към клетъчния енергиен метаболизъм. Сред многото нововъзникващи молекули, никотинамид рибозид (NR) се превърна в изгряваща звезда в науката за живота
Докато световното население продължава да остарява, справянето с възрастовия когнитивен спад и физическото влошаване се превръща в голямо научно предизвикателство. През април 2025 г. в Frontiers in Phar беше публикувано новаторско изследване
Introduction: As time quietly passes, have you noticed your once lively dog becoming slower to respond or experiencing disrupted sleep? Don’t worry — science is bringing new hope! The latest clinical trial h
Global population aging is becoming increasingly pronounced. It is estimated that by 2050, the number of people aged 65 и above will reach 1.6 billion—double the 780 million recorded in 2020. As aging progresses,
Тук е ново авторитетно изследване! Експеримент от 2025 г. на екипа на Northwest A&F University, публикуван в Journal of Microbiology (Core Journal, DOI: 10.13343/j.cnki.wsxb.20250174), разкри с стриктен анализ
September 29, 2025 — After nearly three years of pressure from the Natural Products Association (NPA), the U.S. Food и Drug Administration (FDA) has reversed course и confIRmed that Beta (β) Nicotinamide M
In recent years, “N-series” anti-aging dietary supplements represented by NMN и NR have continued to gain popularity in markets across Europe, the U.S., Japan, и China. The core mechanism of these product
In the world of nutrition, some substances have existed for over a hundred years but have only recently been recognized for theIR great value. Ergothioneine (EGT) is such a modest yet precious dietary component. △ Ch
Според последните изследвания, публикувани в авторитетни списания като *Nature Metabolism*, човешките метаболомни данни показват нелинейни драматични промени между 30 и 50 години. Те включват липидния метаболизъм imb
Do you often feel exhausted? Struggled with blood sugar issues for years? Or perhaps you’re seeking anti-aging solutions и vibrant health? Today, let’s explore a powerful “energy key” hidden dee
NAD+: The Indispensable 'Cell Fuel' и 'RepaIRman' NAD+ is a key coenzyme involved in cellular energy metabolism (e.g., converting food into ATP), DNA repaIR (e.g., activating PARP enzymes), и regulat
In an age where the pursuit of 'frozen age' и 'reverse growth' is on the rise, anti-aging is no longer a distant dream. The core molecule—NAD+ (Nicotinamide Adenine Dinucleotide)—plays a cri
С нарастването на обществения интерес към здравословното стареене и дълголетието, изследванията върху метаболизма на NAD⁺ (никотинамид аденин динуклеотид) набират значителна скорост. NMNH (редуциран никотинамиден мононуклеотид), реду
Женшенът, легендарна билка в традиционната медицина, се използва от хилядолетия заради многобройните си здравословни ползи. В центъра на неговата лечебна мощ стоят гинсенозидите – мощни сапонини, които са събудили интереса на модата
Женшенът, почитан векове наред в традиционната китайска медицина, е корен, известен със своите забележителни терапевтични свойства. В основата на нейната ефективност стоят гинсенозиди, разнообразна група сапонини, считани за активни
Nicotinamide Adenine Dinucleotide Phosphate (NADP), a crucial coenzyme in cellular metabolism, serves as a cornerstone in numerous biochemical reactions. As a derivative of NAD, it adds a phosphate group which enhan
Светът на биохимията е изпълнен с молекули, които, макар и не винаги в светлината на прожекторите, играят критична роля в поддържането и регулирането на клетъчните процеси. Сред тях се отличават окислените коензими
В сложния свят на биохимията коензимите играят ключова роля в улесняването на множество метаболитни реакции, жизненоважни за живота. Един такъв ключов коензим е никотинамид аденин динуклеотид фосфат (NADP). Това
В света на натуралните подсладители стевията е заела значителна ниша благодарение на изключителната си сладост и здравословни ползи. Получен от листата на растението Stevia rebaudiana, този подсладител без калории
In the world of dietary substances, every detail matters—from the source of the ingredients to the color of the final product. For those curious about the health benefits of Nicotinamide Mononucleotide Hydrogen (NM
В развиващия се свят на здравословните и уелнес вещества, търсенето на по-ефективни решения за борба със стареенето и подобряване на клетъчното здраве е непрекъснато. Сред водещите среди тези постижения е използването на NAD+ enh
In the expansive world of biochemical research и health preservation, certain compounds emerge as particularly significant due to theIR potential applications и benefits. One such compound is NMNH, which sta
Nicotinamide adenine dinucleotide hydrogen (NADH) is a lesser-known yet crucial molecule in the biological sciences и various health-related fields. In this blog, we explore the wide-ranging applications of NA
В стремежа към поддържане на младата енергия и здраве с напредване на възрастта, научните изследвания продължават да въвеждат нови вещества, които могат да помогнат в това търсене. Един от най-обещаващите от тях е бета-никотинамид Монону
In the quest for optimal health и vitality, understиing the role of coenzymes in cellular function is paramount. Nicotinamide Adenine Dinucleotide Hydrogen (NADH) is one such coenzyme that plays a critical r
Никотинамид аденин динуклеотид (NAD+) е основен стълб на клетъчното здраве, играейки ключова роля в производството на енергия и метаболитните процеси, които поддържат живота. С напредването на възрастта нивата на NAD+ естествено намаляват, като олово
Energy metabolism is a crucial biological process that involves converting food into the energy needed to power all cellular activities. It is fundamental to maintaining health, vitality, и overall well-being. One
В областта на здравето и благополучието поддържането на оптимална клетъчна функция е ключово за общата жизненост и дълголетие. Една молекула, която е централна за множество биологични процеси, е никотинамид аденин динуклеотид, com
В стремежа към жизненост и дълголетие, научните пробиви около никотинамид-мононуклеотид (NMN) привлякоха вниманието на здравните ентусиасти по целия свят. BONTAC, лидер в биохимичните иновации
В стремежа към здраве и дълголетие, научните пробиви често ни водят до естествени съединения, които могат значително да подобрят нашето благосъстояние. Едно такова съединение, което е привлякло вниманието на здравето и благополучието
В бързо развиващия се сектор на биотехнологиите, продукти, получени от биологични процеси и организми, преоформят индустриите от здравеопазване към земеделие. Пазарът на биотехнологични продукти е изключително конкурентен, Уисконсин
В динамичния свят на здравето и биотехнологиите, клетъчното подмладяване се откроява като революционна концепция, обещаваща нова ера на подобрено здраве, продължителна младост и подобрено качество на живот. Като лидер в glo
In the rapidly evolving lиscape of health и wellness, metabolism-boosting products have emerged as key components in enhancing human health, optimizing metabolic processes, и supporting various bodily functi
Introduction In the realm of animal husbиry, feed additives are necessary as they can not only improve the nutritional value of feed и optimize the internal envIRonment of the rumen, but also enhance
Introduction Nicotinamide adenine dinucleotide (NAD) deficiency has been linked to a range of renal disorders, encompassing conditions such as acute kidney injury, diabetic nephropathy, adenine-triggered kidney diseas
Introduction In response to the escalating global obesity rates, the demи for sugar reduction has reached a critical juncture. As a strategic pivot, the food industry has increasingly incorporated sugar substitutes,
Introduction Parkinson's disease (PD), known as the silent killer, has emerged as the second most common chronic neurodegenerative disease in the world after Alzheimer's disease, affecting
Introduction Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme in cells, a central cofactor of redox reaction и a central regulator of various metabolisms in the human body. It is involved in a
Introduction Spinal cord injury (SCI) can lead to severe impaIRments in motor, sensory, и autonomic nervous system functions. It has been reported that motor function recovery can be promoted by mediatin
Introduction Chronic cerebral hypoperfusion (CCH) has been identified as one of the initial conditions critical to the development of cognitive impaIRment, which is tightly associated to the complex neurologic
Introduction Stroke remains the second leading cause of death и the thIRd leading cause of death и disability combined in the world, as reported in 2019 Global Burden of Disease Study. Ischemic stroke
Introduction Myocardial ischemia/reperfusion (MI/R) can damage the heart muscle, which may contribute to further cardiomyocyte death. Following percutaneous coronary intervention therapy, patients with MI/
Introduction According to the report by World Health Organization (WHO) in 2017, depression is the thIRd leading cause of the global disease burden, with over 300 million people suffering from this disease w
Thanks to our unrelenting dedication to creating cutting-edge solutions that push the frontiers of scientific development, BONTAC has long been at the forefront of the biochemical sector. We are excited to present o
Our unshakable dedication to maximizing the potential of traditional Chinese medicine has propelled BONTAC to the forefront of the natural products sector for a considerable amount of time. We are thrilled to presen
Нашето непоколебимо търсене на иновации в BONTAC has always been sparked by our profound grasp of the natural world и its unrealized potential. We are excited to present our ground-breaking solutions today, which are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries и improve lives, we at BONTAC have long been at the forefront of the green biotechnology revolution. We are
With an unwavering zeal for creating innovative solutions with the potential to revolutionize industries и improve lives, BONTAC has long been at the forefront of the green biotechnology revolution. We are ex
For many years, BONTAC has been acknowledged as a leader in the field of green biotechnology, thanks to our unwavering commitment to creating ground-breaking products и services that have the potential to improve
Because of our unwavering search for products that have the power to genuinely change the lives of our partners и consumers, we at BONTAC have long been at the forefront of cutting-edge green biotechnology solutio
Being deeply aware of the vital role our products play in enabling people to live healthier, more fulfilling lives has always motivated us at BONTAC to innovate. We are pleased to announce our ground-breaking NMNH,
Propelled by an unwavering dedication to innovation и a profound comprehension of the crucial function this coenzyme plays in preserving cellular health и lifespan, BONTAC has been at the forefront of the NAD+ a
At BONTAC, we have always been driven by a relentless pursuit of innovation – a desIRe to push the boundaries of what is possible in the realm of nutritional supplements и biomedical research. Today, we are thril
В BONTAC отдавна сме страстни към търсенето на най-съвременни хранителни решения, които наистина могат да трансформират човешкото здраве и благополучие. Днес сме развълнувани да хвърлим светлина върху един от най-забележителните
В BONTAC винаги сме били в авангарда на най-новите нутрицевтични изследвания, посветени на разкриването на най-забележителните и трансформиращи съединения, които природата може да предложи. Днес с удоволствие ви представяме
For many years, BONTAC has been at the forefront of innovative biopharmaceutical developments, committed to maximizing the life-changing potential of nature's most extraordinary substances. We are excited to pre
В BONTAC отдавна сме в авангарда на иновациите в областта на биофармацевтиката, посветени на използването на силата на най-новите научни открития за подобряване на живота на тези, на които служим. Днес ние
В BONTAC сме движени от дълбок ангажимент да овластим хората с необходимите инструменти, за да постигнат оптимално здраве и благополучие. Като лидери в индустрията в областта на биотехнологиите, ние сме се посветили на себе си
В BONTAC нашата мисия е да овластим хората с инструментите, от които се нуждаят, за да постигнат оптимално здраве и благополучие. Като пионер в областта на биотехнологиите, ние сме се посветили на разкриването на дълбокото благо
В BONTAC сме дълбоко ангажирани с разширяването на границите на човешкото здраве и благополучие. Като водещ иноватор в областта на биотехнологиите, ние сме фокусирани върху използването на невероятния потенциал на Beta-Nicoti
As a leading player in the world of biotechnology, BONTAC is at the forefront of driving innovation и transforming the industry. Our unwavering commitment to scientific excellence и our deep understиing of the
В BONTAC сме движени от неуморен стремеж към иновации и дълбок ангажимент към подобряване живота на тези, на които служим. Като лидери в областта на клетъчното здраве и подмладяването, с нетърпение представяме нашите
В BONTAC сме начело на индустрията за продукти, стимулиращи метаболизма, водени от нашия непоколебим ангажимент към иновациите и стремежа към научно съвършенство. Нашият фокус върху разработването на най-съвременни решения h
Introduction With changes in lifestyles и dietary structure, hyperuricemia shows an increasing prevalence year by year, which may become the second largest metabolic disease after diabetes mellitus, a
Introduction Steviol glycosides are secondary metabolites obtained by extracting и isolating stevia from the herbaceous plant Stevia rebaudiana of the Asteraceae family, with a high degree of sweetness
NAD is an abbreviation for nicotinamide adenine dinucleotide, which is a naturally occurring coenzyme (a substance that works with enzymes) found in our bodies. It helps cells produce energy. However, as we age, NAD
Introduction According to the report of International Agency for Research on Cancer (IARC), there are 19.3 million new cases of malignant tumors и 10 million deaths worldwide in 2020. Malignant tumors have overtaken
Introduction Elderly individuals are at a significantly higher risk for peripheral artery disease (PAD), a common vascular disorder. As the global population ages rapidly, the number of PAD cases is projected to rise
Introduction Diabetic kidney disease (DKD) has emerged as one of the primary cause of mortality among the patients with end-stage renal disease such as renal failure, accounting for 30-50% of chronic renal failure cas
Introduction Nicotinamide adenine dinucleotide (NAD+) metabolism is essential for maintaining normal physiological activities, и the decreased NAD+ level is related to various pathologies such as cardiac dis
Introduction Targeting the autophagy-NAD axis has been reported be a viable therapeutic strategy for Niemann-Pick type C1 (NPC1) disease. The study suggests that both pharmacological rescue of autophagy deficiency и
Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus
Introduction Amoebiasis has emerged as the thIRd most common cause of death by parasites worldwide after malaria и schistosomiasis infections. According to the report of World Health Organization, over 40 milli
Introduction Disturbance in hepatic NAD+ metabolism has been manifested as a key factor in the initiation и progression of nonalcoholic fatty liver disease (NAFLD), one of the most co
Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death и disability up to 2030. There are 50~60
Introduction In clinical settings, doxorubicin (DOX) is an effective broad-spectrum anti-cancer drug in chemotherapy for various tumors, including hematological malignancies и solid tumors such as leu
Introduction Cigarettes containing nicotine (Nic) и sugar-sweetened beverages (SSBs) with high fructose corn syrup (HFCS) have been uncovered to induce hepatic steatosis, which are the risk factors for the developme
Introduction Acute promyelocytic leukemia (APL), the M3 type of acute myeloid leukemia (AML), typically relies on all-trans retinoic acid (ATRA) as its primary treatment. While APL patients treated with
Introduction Recent research unveils that hepatic insulin resistance (IR) и steatosis in obesity have a strong association with endoplasmic reticulum (ER)-mitochondria miscommunication. Notably,
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN po
Introduction In the presence of oxygen, tumors produce adenosine triphosphate (ATP) through glycolysis instead of mitochondrial oxidative phosphorylation, a phenomenon known as the “Warburg effect”. Aerobi
Introduction Age-related macular degeneration (AMD) has become one of the leading cause of low vision и even blindness in the elderly, especially in those above 50. In 2020, approximately 1.8 million people aged ove
Introduction Natural products, including single components or extracts of herbal medicines, have the features of good efficacy и low toxicity when used in tumor treatment. They have unique advantages in treating dis
Introduction Reproductive dysfunction is frequent in female suffering from type 1 diabetes (T1D), up to 40% of whom will develop a variety of reproductive dysfunctions throughout theIR lives. T1D patients often ha
In today's health и anti-aging fields, NMN (nicotinamide mononucleotide) has attracted a lot of attention. As an important cellular coenzyme, NMN plays a key role in maintaining cell health и delaying the aging p
Introduction Гинсеносайд Rg3 (Rg3) holds great promise as a potential drug for preventing scar formation, but it is often difficult for it to work alone due to its poor water solubility и low bioavail
Introduction Lead (Pb) contamination in aquatic envIRonments poses a significant threat to the health и well-being of aquatic organisms, including fish species. There is rising popularity of prebiotics и probi
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Revolutionizing Biotechnical Research: BONTAC's Trailblazing Discoveries In the dynamic realm of biotechnical research, BONTAC stиs at the forefront of innovation, dedicated to driving progress и breakthr
Elevating Health with BONTAC's Cutting-Edge Longevity Supplements In the realm of health и wellness, the demи for high-quality metabolism-boosting supplements continues to rise. At BONTAC, we recognize the c
Introduction It has been reported that infection with Gram-negative bacteria can disrupt the osteogenic differentiation. Notably, nicotinamide mononucleotide (NMN) protects against osteogenesis from inflammat
Pioneering Discoveries: BONTAC's Innovations in Biotechnical Research In the dynamic realm of biotechnical research, BONTAC stиs at the forefront of innovation, dedicated to driving progress и breakthroug
Подхранващо здраве: BONTAC е водещ доставчик на суровини на добавки As a prominent raw material supplier of supplements, BONTAC is dedicated to developing и delivering premium products that promote he
Unleash Vitality и Renewal: BONTAC's Cutting-edge Cellular Rejuvenation Solutions Cellular Rejuvenation plays a vital role in enhancing vitality и promoting overall wellness. At BONTAC, we are dedicated t
Introduction Hepatocellular carcinoma (HCC) is hypervascular solid tumor with rapid deterioration, poor overall prognosis и a high recurrence rate, accounting for 90% of primary liver cancers, which ha
Повишаване на благосъстоянието: BONTAC Advanced суровини за добавки за клетъчно здраве In today's fast-paced world, the quest for optimal health и wellness has led to a surge in the demи for high-quality cellular
Powering Health и Vitality: BONTAC's Metabolism-boosting Product Portfolio In the dynamic lиscape of health и wellness, the demи for cutting-edge metabolism-boosting products continues to
Unlocking the Power of Metabolism-Boosting Supplements: A Guide by BONTAC In the realm of health и wellness, the demи for high-quality metabolism-boosting supplements is steadily rising. At BONTAC,
Introduction Artificial insemination with chilled ram semen is commonly used method in livestock industry. But storing sperm in chilled conditions may cause changes in sperm membrane function и structure, и
Introduction In light of a statistics report by World Health Organization (WHO), there are 18 million people suffering from rheumatoid arthritis (RA) worldwide in 2019, where the prevalence of female is 2.5 times
Introduction Glaucoma is regarded as the second dominant cause of blindness across the world. With the amounting number и proportion of elderly people, it is estimated that 111.8 million people will have glaucom
Introduction Triocresyl phosphate (TOCP) is widely used in the realm of industry и agriculture in the last century. However, it is subsequently banned due to the increasing understиing of its toxicity. In
Introduction Cardiovascular diseases (CVD) poses huge economic burden и great threat to the life of patients, even surpassing Alzheimer's disease и diabetes. 17.9 million people in the world
Introduction Myocardial ischemia-reperfusion (I/R) injury has emerged as an urgent clinical issue that may offset the benefits of reperfusion therapy и even worsen the prognosis of acute myocardial infarction, a
.two-side{ text-align: justify; display: flex; justify-content: space-between; } Introduction The crucial parts of nicotinamide adenine dinucleotide (NAD+) и its metabolites in aging a
Introduction Гинсеносайд Rh2 nanoliposome formulation has been proved to effectively target и deliver drugs to the tumor site, with less side effects и higher treatment efficiency, holding great promise in the
Introduction Replenishing nicotinamide mononucleotide (NMN) to raise the availability of nicotinamide adenine dinucleotide (NAD+) has been deemed as effective approach to prevent neurodegeneration in aging и pat
Introduction Rare ginsenoside Rg3, an active extract from Panax ginseng, is reported to possess a wide range of pharmacological properties including anti-angiogenesis и anti-cancer, with high lipophilicity (esti
Introduction Wound healing is a sophisticated process responding to tissue damage, which is associated with numbers of interaction of various cell types, cytokines, growth factors, и other molecules. Strikingly,
Introduction Diabetes is one of the dominant causes of death и disability worldwide, greatly affecting the life quality of patients. According to the latest data on diabetes released by the Lancet (GBD Study 202
Introduction Intervertebral disc degeneration (IDD) is a frequently seen orthopedic disease, which is accompanied with excessive apoptosis of nucleus pulposus cells (NPCs) и degeneration of extracellular ma
Introduction Гинсеносайд Rg3 is Panaxanediol type tetracyclic triterpenoid saponin monomer extracted from the root of Panax ginseng, which has a wide range of pharmacological effects including anti-tumor, neuroprotect
Introduction The gut is a diverse и dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, и aerobic bacteria. In the pr
Introduction Mar 4th is determined as the World Obesity Day. World Obesity Federation, UNICEF и WHO have hosted a global youth-led webinar to talk about obesity & youth. The obesity crisis has gradually attr
Introduction Nicotinamide mononucleotide (NMN), one precursor of nicotinamide adenine dinucleotide (NAD+), has been ascertained to be implicated with multiple biological processes such as cellular redox regulation и
Introduction Alpers' disease is both a neurodegenerative disorder и a metabolic disorder, which is tightly linked to mitochondrial dysfunction и mutations in the catalytic subunit of polymerase
Introduction NADH (reduced form of NAD+) serves as a carrier of biological hydrogen и an electron donor, which participates in diverse physiological processes such as protein synthesis, DNA repaIR,
Introduction Гинсеносайд Rh2, one protopanaxadiol (PPD)-type rare ginsenoside in Panax ginseng, is uncovered to possibly have broad-spectrum pharmacological activity in diversified tumors. It is utili
Introduction Solute carrier family 25 member 51 (SLC25A51) is perceived as a mammalian transporter, which is capable of importing oxidized nicotinamide adenine dinucleotide (NAD+) into mitochondrial matrix. Remark
Introduction Oxidized form of nicotinamide adenine dinucleotide (NAD+) и its precursor nicotinamide mononucleotide (NMN) have been uncovered to restore DNA repaIR и prevent cancer progression via the deleted i
1. Introduction Disrupted nicotinamide adenine dinucleotide (NAD+) metabolism is increasingly deemed to be one of risk factor for amendable cardiovascular disorders. A substantial evidence has mIRrored that res
1. Introduction Rare ginsenosides, a group of dammarane triterpenoids that exist in low natural abundance, fuels a high concern from scholars recently, showing great potential as shining components in drugs и nu
1. Introduction Nicotinamide adenine dinucleotide (NAD) has been unveiled to be essential for embryonic development. Patients with genetic variants in the NAD+ de novo synthesis pathway often have congen
1. Introduction The gut microbiota has long been regarded as one of the key elements contributing to the regulation of host health. Any changes in the composition or quality of the gut microbiota may have physiolo
1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation и gene expression, in addition to controlling glucose metabolism. White adipose tiss
1. Introduction Nicotinamide mononucleotide (NMN) supplementation has been suggested to hamper the inflammatory responses via restoring NAD+ level и downregulating the expression of C
1. Introduction Age-related NAD+ depletion affects physiological functions и contributes to various aging-related diseases. NAD+ precursors can significantly elevate NAD+ level in murine tissues, effectivel
1. Introduction In mammalian cells, the majority of NAD+ is produced from metabolites entering the NAD+ salvage pathway. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme of the salvage
Nmnh, известен още като никотинамид мононуклеотид хидрат, е жизненоважен коензим, който се намира във всички живи клетки. Той играе ключова роля в клетъчния метаболизъм, производството на енергия и различни биосинтетични процеси. Висока чистота N
В сферата на здравословните добавки, NADH се откроява като ключов коензим, участващ в клетъчния метаболизъм. Значението му за поддържане на енергийните нива и подкрепата на общото благосъстояние го е превърнало в ценна съставка за
1. Introduction Nicotinamide Mononucleotide (NMN) has been deemed as a functional nutrient for improving human intestinal health. In this study, an in vitro simulated digestion model
1. Introduction Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects the motion-related nerve cells in the brain и spinal cord. The disease is featured by the d
1.Introduction A series of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease и Huntington's disease, are accompanied with bioenergetic maladaptations и axonopathy wi
1. Introduction Diabetic peripheral neuropathy (DPN) is one of the most frequent complications of diabetes, ans also a major cause of foot ulcers, disability, и eventual amputation. With the prolongation of the
1.Introduction Mitochondria, a type of highly plastic organelle, can maintain a relatively stable dynamic equilibrium state towards the morphology, structure, quantity, volume, quality, и function
1. Introduction Atherosclerosis is a chronic progressive inflammatory disease, which is featured by the accumulation of lipids in the intima of the arteries with yellow appearance. This disease
1. Introduction Mitochondria are the center of energy metabolism in cardiomyocytes, which are necessary for maintaining normal myocardial contractility и cardiac function. Typically, the de
1. Introduction According to the 2020 report of World Health Organization (WHO), there are approximately 2.3 million cases with breast cancer worldwide. Breast cancer has emerged as one of the
1.Introduction The senescence in mammals is generally concomitant with the dysregulation of intestinal homeostasis и the accumulation of mitochondrial DNA (mtDNA) mutations. High-burden mtDNA mutations lead to N
1. Introduction At present, vaccine is the preferred option for the prevention of foot-и-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated wi
1. Introduction Acute lung injury comprises a uniform response of the lung to inflammatory or chemical insults which is commonly caused by systemic illness including sepsis or trauma, infection with pathogens, и tox
1. Introduction Gastric cancer (GC) represents a global health-care challenge, which is the fifth most common cancer и the fourth leading cause of cancer death across the world in 2020, with a significant
1. Introduction Supplementation of nicotinamide mononucleotide (NMN) to upregulate the level of nicotinamide adenine dinucleotide (NAD+) has been unveiled to be a promising anti-aging intervention. However, it is
1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems и lipid synthesis, which links insulin
1. Introduction Dengue fever is an acute infectious disease caused by the Dengue vIRus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as hi
1. Introduction The NAD precursor nicotinamide mononucleotide (NMN) shows a beneficial effect on ageing, yet excessive NMN accumulation may lead to axon degeneration. How to make the anti-ageing
1 Introduction Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (a
1. Introduction Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in
1. Introduction Ginseng has always been highly perceived as a valuable traditional Chinese medicine in China. Currently, much attention also has been paid to ginsenosides, the main active ingredients extracted from g
1. Introduction On July 2023, the World Health Organization (WHO) has classified the soda sweetener aspartame as a possible carcinogen, but said that aspartame is safe to consume with
Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial disorders are associated with various cardiac diseases. Mitochondrial translation defects cause not only mitochondrial
Възпалителната реакция и нарушаването на кожната бариера, причинени от оксидативния стрес, играят ключова роля в процеса на атопичен дерматит (AD). Нивата на липидна пероксидация често са по-високи при пациенти с AD, докато анти
Витамин D и B3 (ниацин) могат да подпомогнат имунната активация и възстановяването на CD4+ T клетките в INR. NAD, жизненоважен за клетъчната функция, намалява с възрастта и се свързва с различни заболявания. Поддръжници на NAD като NMN, NR и NAM шоу на бала
Sepsis, marked by dysregulated infection response, lacks effective treatment. NAD+'s role in inflammation remains unclear. NAD+ transport challenges limit its therapeutic impact. Novel NAD+-loaded nanoparticles (NPs)
В клиничната диагностика ензимите са важни биокатализатори и играят ключова роля в много биохимични реакции. Тези ензими изискват коензими, които наричаме диагностични реагентни коензими, за да изпълняват функциите си.
Кръвно-мозъчната бариера (BBB) е критичен компонент на централната нервна система, който регулира обмена на молекули между мозъка и кръвния поток. Възрастовите промени в BBB могат да доведат до увеличаване на
Съдовата деменция е един от сериозните и необратими синдроми на придобита интелигентност и увреждания, причинени от серия цереброваскуларни заболявания. Цитиколинът е производна на нуклео-страната, която не само може да екзи
In the quest for a healthier lifestyle, the sweetener debate continues to rage. While sugar has long been the default choice, its adverse health effects have prompted a search for alternatives. One such swe
The nicotinamide adenine dinucleotide (NAD+ )/reduced NAD+ (NADH) и NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis и for modulating numerous biologic
Хипертонията е сериозен глобален здравен проблем, свързан с милиони смъртни случаи поради сърдечно-съдови проблеми. Тя включва ендотелна дисфункция и скованост на артериите, което допринася за атеросклеротични заболявания. Подобряване на VA
Диетите с високо съдържание на захар доведоха до нарастваща честота на различни хронични заболявания, включително затлъстяване, диабет, сърдечно-съдови заболявания и хипертония, което представлява значителен глобален общественоздравен проблем. Стевия Ребаудиосид
CFS is a disorder of unknown etiology, consisting of prolonged, debilitating fatigue, и a multitude of symptoms including neurocognitive dysfunction, flu-like symptoms, myalgia, weakness, arthralgia, low-grade fev
Алкохолът е вид психоактивно вещество, което е било широко използвано в няколко култури в продължение на векове. Приемът на алкохол е основната причина за остро увреждане на черния дроб и хронични чернодробни заболявания. Алкохолизмът може да ускори човека
Стевия (Stevia rebaudiana Bertoni), многогодишен храст от семейство Compositae, се култивира в много региони по света. Той е известен със своята сладост, която се дължи на наличието на стевиол гликозиди, като има 1
Стевиозид е естествен подсладител, получен от растението стевия. Той има висока интензитет на сладост и нискокалорично съдържание, което го прави привлекателен за диабетици и други на диети с контрол на въглехидрати. Въпреки това, стевиос
Highlight: In chronic HBV infection elevated ROS production is associated to high DNA damage in HBV-specific CD8 T cells - Response to DNA damage is dysfunctional - Up-regulation of CD38 и persistent activatio
In the pass decades days, the Open AI и the amazing founder behind AI application both captured attention world widely. But recently, as MIT Technology Review reported, the OpenAI CEO Sam Altman has turned ou
NMNH силно засилва NAD+ и потиска гликолизата, цикъла на TCA и растежа на клетките NAD+ is essential for biological processes such as metabolism и DNA repaIR, и its decline is associated with age-related diseas
Гинсеносайдs on Cancer и Related Clinical Studies Cancer is a leading cause of death globally, и its treatment often involves a combination of surgery, chemotherapy, и radiation therapy. These treatm
Инженерство на ензими, свързано с растеж, чрез манипулация на регенерация на редокс кофактора An increasingly wide range of chemicals are now being produced from renewable feedstocks through biotechnological means. Biopro
Supervision Policies for NMN in Japan, China, America, Australia и Canada The mainstream researches of NMN have been conducted since a decade years ago. The United States had already carried out its commerciali
Collections of Clinical Trails on NMN Oral Administation NMN, as one of NAD+ booster family critical members, become increasingly popular on the market in the filed of health pomoting. And to date, there are
С разхлабването на политиките за контрол на епидемиите по света, жителите на Китай, Индия, Малайзия, Япония и Сингапур страдат от недостиг на лекарства в различна степен. Но от друга страна, видът лекарства
Attention! The Cambridge University Researchers Found Ursodeoxycholic Acid (UDCA) Can Prevent и Treat Covid-19 The International academic journal Nature published an article titled FXR inhibition may protect from SARS
На 10 август 2021 г. изследователи от Шанхайския университет по наука и технологии публикуваха статия, озаглавена "NAD+ добавката подобрява функцията за убиване на тумори чрез спасяване на дефектен TUBBY-медииран NAMPT транскрип"
