Предимства на НПМ
НПМ: 1. "Bonzyme" Цялостен ензимен метод, екологичен, без вредни остатъци от разтворител на прах за производство. 2. Bontac е първият производител в света, който произвежда прах НПМ на ниво на висока чистота, стабилност. 3. Изключителна технология за пречистване в седем стъпки "Bonpure", висока чистота (до 99%) и стабилност на производството на прах от НПМ 4. Самостоятелни фабрики и получили редица международни сертификати, за да осигурят високо качество и стабилни доставки на продукти от НПМ на прах 5. Осигурете услуга за персонализиране на продуктово решение на едно гише
Предимства на НАДХ
НАДХ: 1. Бонзимен пълноензимен метод, екологичен, без вредни остатъци от разтворители 2. Изключителна технология за пречистване в седем стъпки на Bonpure, чистота над 98% 3. Специална патентована форма на технологичен кристал, по-висока стабилност 4. Получи редица международни сертификати, за да гарантира високо качество 5. 8 местни и чуждестранни патента на НАДХ, водещи в индустрията 6. Осигурете услуга за персонализиране на продуктово решение на едно гише
Предимства на НАД
НАД: 1. "Bonzyme" Цялостен ензимен метод, екологичен, без вредни остатъци от разтворители 2. Стабилен доставчик на 1000+ предприятия по целия свят 3. Уникална технология за пречистване в седем стъпки "Bonpure", по-високо съдържание на продукта и по-висок процент на конверсия 4. Технология за сушене чрез замразяване за осигуряване на стабилно качество на продукта 5. Уникална кристална технология, по-висока разтворимост на продукта 6. Самостоятелни фабрики и получи редица международни сертификати, за да гарантира високо качество и стабилни доставки на продукти
Предимства на MNM
НМН: 1. "Bonzyme"Цялостен ензимен метод, екологичен, без вредни остатъци от разтворител 2. Изключителна технология за пречистване в седем стъпки "Bonpure", висока чистота (до 99,9%) и стабилност 3. Водеща индустриална технология: 15 местни и международни патента на НМН 4. Самостоятелни фабрики и получи редица международни сертификати, за да гарантира високо качество и стабилни доставки на продукти 5. Множество in vivo проучвания показват, че Bontac НМН е безопасен и ефективен 6. Осигурете услуга за персонализиране на продуктово решение на едно гише 7. Доставчик на суровини НМН на известния екип на Дейвид Синклер от Харвардския университет
Имаме най-добрите решения за вашия бизнес
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global НМН industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 патента за изобретения. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
Методи за производство на НМН прах, използвани от производителите
НМН прахът обикновено се произвежда чрез химичен или ензимен синтез или ферментационна биосинтеза. И трите метода имат плюсове и минуси.
Chemical synthesis is expensive and labor intensive, and all raw ingredients used are categorized as “unnatural,” i.e., not from biological systems. There are, however, some advantages from the manufacturer’s perspective. The yield is well suited to mass НМН powder production, and all of those unnatural raw ingredients can be carefully controlled. But there are a number of drawbacks as well. Some of the solvents used in the manufacturing process are seriously bad from an environmental standpoint, and impurities and by-products can be challenging to remove from the finished product – that’s seriously bad for the consumer.
Enzymatic production of НМН powder, on the other hand, is considered a “green preparation method.” Like the chemical route, it’s pricey, but it offers a higher yield and impressively high purity. The finished НМН ticks all the boxes – stable, easily absorbed, lightweight, low density, and a low molecular structure.
Ферментацията също е изследвана като метод за производство на НМН, но добивът, макар и с високо качество, е доста ужасен, така че много компании за добавки доста разумно гледат към други, по-ефективни процеси.
Внимавайте с измамните продукти на НМН на пазара
According to recent industrial report, only several products from worldwide НМН manufacturers came close to meeting label claim and contain not enough НМН. Almost products performed better, having at least 88% of the label claim up to small overages. A lone 250 mg product was identified as BRL. In sum, ChromaDex said that 64% of the products tested contained less than 1% of the stated amount of the active ingredient. which should give consumers pause. While this is a limited snapshot of the vast НМН finished product landscape. it does provide a glimpse into the high variability of product quality that is available. The majority of the products may purchase online contain such a small amount of НМН that there would be no clinical benefits achieved from the dose. Another concern with these adulterated products is that the actual contents are not known and could pose a risk to the user the company said in a statement.
Характеристики и предимства на продукта BONTAC НМН
1、“Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder
2、Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability of production of НМН powder
3、Водеща индустриална технология: 15 местни и международни патента на НМН
4、Самостоятелни фабрики и получиха редица международни сертификати, за да осигурят високо качество и стабилни доставки на продукти от НМН прах
5、Множество проучвания in vivo показват, че прахът Bontac НМН е безопасен и ефективен
6、Осигурете услуга за персонализиране на продуктово решение на едно гише
7、НМН доставчик на суровини на известния екип на Дейвид Синклер от Харвардския университет.
Потребителски рецензии
Какво казват потребителите относно BONTAC
Често задавани въпроси
Имате ли някакъв въпрос?
1. Процес на производство на суровини
Биоензимната катализа е популярен метод за производство в индустрията. Той има висок праг и няколко ключови каталитични ензима са скъпи, представляващи около 80% от общите разходи за производствения процес, но също така е и най-безопасният и ефективен метод за производство. При производството на НМН чрез биоензимна катализа използването на хранителни суровини е важна част от процеса, за да се гарантира безопасността на продукта и да се гарантира спазването на стандартите.
2. Висок стандарт на производствените условия
Производствените условия се отнасят до стандарта на разхода на труд, необходим за завършване на квалифицираните продукти на единицата при определени условия на производствена организация и производствена технология. Има сертификати, издадени от регулаторни органи, като cGMP в Съединените щати, TGA в Австралия, GMP в Япония и др.
3. Висок стандарт на тестване на продукта.
Тестването на продукта изисква надеждни методи за изпитване и реагенти, които се използват през целия производствен процес. Те са не само стандарти за проверка на крайния продукт, но и за междинните етапи на контрол, включително тестване на активни съставки, тестване на тежки метали като олово, арсен и живак и тестване на патогенни бактерии, микроорганизми и странични продукти от преработката.
За продуктите на НМН често използваният метод за тестване на съдържанието на активните съставки е високоефективната течна хроматография (HPLC), която е ефективна, точна и прецизна. За различните производители стандартите за тестване на реагенти са различни. Строгите производители ще купуват аналитично чисти реагенти с висока чистота от компании за стандарти на трети страни като контрол.
4.Оценка на безопасността
За сравнително нови суровини като НМН не е достатъчно потребителите да преценяват безопасността на продукта само от страна на търговеца. На този етап докладът за оценка на трета страна е особено важен.
В момента има два общи доклада за оценка на безопасността, единият е доклад за токсикологична оценка, а другият е доклад за оценка на безопасността. В Китай докладите за токсикологична оценка обикновено представляват мнозинството. Все още обаче има малко компании от НМН, които могат да издават такива доклади
5. Съхранение и опаковане
НМН обикновено се съхраняват в запечатани контейнери до 12 месеца. Ако може да се съхранява 24 месеца с незначителни промени в чистотата, стабилността на НМН е много надеждна. В момента по-често срещаните опаковъчни материали са pet или hope, които са фармацевтични опаковъчни материали. Те са нетоксични, без мирис, леки, преносими и ефективно изолират въздуха и влагата.
Безопасността на НМН прах не може да бъде оценена, тъй като все още не са завършени необходимите клинични и токсикологични изследвания, за да се установят препоръчителните безопасни нива за продължително приложение. Въпреки това тяхната безопасност и ефикасност са несигурни и ненадеждни, тъй като повечето от тях не са подкрепени от строги научни предклинични и клинични тестове. Този въпрос е възникнал, тъй като производителите се колебаят да плащат за изследвания и клинични изпитвания поради потенциално по-нисък марж на печалба и няма упълномощаваща агенция, която да регулира продуктите на НМН, тъй като те често се продават като функционален хранителен продукт, а не като силно регулирано терапевтично лекарство. Ето защо групите за защита на потребителите изискват по-строг процес на одобрение, които искат от регулаторните агенции да определят стандарти и ограничения за пускане на пазара на здравни продукти против стареене, като се има предвид безопасността, здравето и благосъстоянието на потребителите. НМН не трябва да се разглежда като панацея за възрастните хора, тъй като повишаването на нивата на НАД, когато не е необходимо, може да доведе до някои вредни ефекти. Следователно, дозата и честотата на добавките с НМН трябва да бъдат внимателно предписани в зависимост от вида на свързания с възрастта дефицит и всички други здравословни състояния на хората. Други прекурсори на НАД са изследвани, за да се открие ефикасността при различни дефицити, свързани с възрастта, и те се използват за определени дефицити, само след като са доказани за ефективност и безопасни за употреба. Следователно същият принцип трябва да се прилага и за НМН
Първо проверете фабриката. След известен преглед, НМН компанират, че потребителите директно се сблъскват, обръщат повече внимание на изграждането на марката. Следователно за добрата марка качеството е най-важното и първото нещо, което трябва да контролирате качеството на суровините, е да инспектирате фабриката. Компанията Bontac всъщност произвежда НМН прах с високо качество с катериите на SGS. Второ, чистотата се тества. Чистотата е един от най-важните параметри на НМН прах. Ако НМН с висока чистота не може да бъде гарантирана, останалите вещества вероятно ще надхвърлят съответните стандарти. Както показват приложените сертификати, НМН прахът, произвеждан от Bontac, достига чистота от 99,9%. И накрая, е необходим професионален тестов спектър, за да се докаже това. Често срещаните методи за определяне на структурата на органично съединение включват ядрено-магнитна резонансна спектроскопия (ЯМР) и масспектрометрия с висока разделителна способност (HRMS). Обикновено чрез анализа на тези два спектъра структурата на съединението може да бъде предварително определена.
Нашите актуализации и публикации в блога
Най-новите изследвания доказват: Коензимът НАД+ може да повиши туморния имунитет! Експертен коментар от Китайската академия на науките
On August 10, 2021, researchers from Shanghai University of Science and Technology published an article titled НАД+ supplement potentiates tumor killing function by rescuing defective TUBBY-mediated NAMPT transcription in tumor infiltrated T cells in Cell Reports, revealing that НАД+ in supplemented during CAR-T therapy and immune checkpoint inhibitor therapy, it can improve the anti-tumor activity of T. At present, the supplementary precursor of НАД+, as a nutritional product,has been verified for human consumption safety.This achievement provides a simply and feasible new method for improving the anti-tumor activity of T cells. Cancer immunotherapies including the adoptive transfer of naturally occurring tumor-infiltrating lymphocytes (TILs) and genetically engineered T cells, as well as the use of immune checkpoint blockade (ICB) to boost the function of T cells, have emerged as promising approaches to achieve durable clinical responses of otherwise treatment-refractory cancers (Lee et al., 2015; Rosenberg and Restifo, 2015; Sharma and Allison, 2015). Although immunotherapies have been successfully used in the clinic, the number of patients benefiting from them is still limited (Fradet et al., 2019; Newick et al., 2017). Tumor microenvironment (TME)-related immunosuppression has emerged as the major reason for low and/or no response to both immunotherapies (Ninomiya et al., 2015; Schoenfeld and Hellmann, 2020). Therefore, efforts to investigate and overcome TME-related limitations in immune therapies are of great urgency. The fact that immune cells and cancer cells share many fundamental metabolic pathways implies an irreconcilable competition for nutrients in TME (Andrejeva and Rathmell, 2017; Chang et al., 2015). During uncontrolled proliferation, cancer cells hijack alternative pathways for more rapid metabolite generation (Vander Heiden et al., 2009). As a consequence, nutrient depletion, hypoxia, acidity, and generation of metabolites that can be toxic in the TME may hinder successful immunotherapy (Weinberg et al., 2010). Indeed, TILs often experience mitochondrial stress within growing tumors and become exhausted (Scharping et al., 2016). Interestingly, multiple studies also indicate that metabolic changes in TME could re-shape T cell differentiation and functional activity (Bailis et al., 2019; Chang et al., 2013; Peng et al., 2016). All these evidences inspired us to hypothesize that metabolic reprogramming in T cells might rescue them from a stressed metabolic environment, thereby reinvigorating their anti-tumor activity (Buck et al., 2016; Zhang et al., 2017). In this current study, by integrating both genetic and chemical screens, we identified that NAMPT, a key gene involved in НАД+ biosynthesis, was essential for T cell activation. NAMPT inhibition led to robust НАД+ decline in T cells, thereby disrupting glycolysis regulation and mitochondrial function, blocking ATP synthesis, and dampening the T cell receptor (TCR) downstream signaling cascade. Building on the observation that TILs have relatively lower НАД+ and NAMPT expression levels than T cells from peripheral blood mononuclear cells (PBMCs) in ovarian cancer patients, we performed genetic screening in T cells and identified that Tubby (TUB) is a transcription factor for NAMPT. Finally, we applied this basic knowledge in the (pre) clinic and showed very strong evidence that supplementation with НАД+ dramatically improves the anti-tumor killing activity both in adoptively transferred CAR-T cells therapy and immune check point blockade therapy, indicating their promising potential for targeting НАД+ metabolism to better treat cancers. 1.НАД+ regulates the activation of T cells by affecting energy metabolism After antigen stimulation, T cells undergo metabolic reprogramming, from mitochondrial oxidation to glycolysis as the main source of ATP. While maintaining sufficient mitochondrial functions to support cell proliferation and effector functions.Given that НАД+ is the main coenzyme for redox, the researchers verified the effect of НАД+ on the level of metabolism in T cells through experiments such as metabolic mass spectrometry and isotope labeling. The results of in vitro experiments show that НАД+ deficiency will significantly reduce the level of glycolysis, TCA cycle and electron transport chain metabolism in T cells. Through the experiment of replenishing ATP, the researchers found that the lack of НАД+ mainly inhibits the production of ATP in T cells, thereby reducing the level of T cell activation. 2.The НАД+ salvage synthesis pathway regulated by NAMPT is essential for T cell activation The metabolic reprogramming process regulates the activation and differentiation of immune cells. Targeting T cell metabolism provides an opportunity to modulate the immune response in a cellular way. Immune cells in the tumor microenvironment, their own metabolic level will also be correspondingly affected. The researchers in this article have discovered the important role of NAMPT in the activation of T cells through genome-wide sgRNA screening and metabolism-related small molecule inhibitor screening experiments. Nicotinamide adenine dinucleotide (НАД+) is a coenzyme for redox reactions and can be synthesized through the salvage pathway, de novo synthesis pathway, and Preiss-Handler pathway. The NAMPT metabolic enzyme is mainly involved in the НАД+ salvage synthesis pathway. Analysis of clinical tumor samples found that in tumor-infiltrating T cells, their НАД+ levels and NAMPT levels were lower than other T cells. Researchers speculate that НАД+ levels may be one of the factors that affect the anti-tumor activity of tumor-infiltrating T cells. 3.Supplement НАД+ to enhance the anti-tumor activity of T cells Immunotherapy has been exploratory research in cancer treatment, but the main problem is the best treatment strategy and the effectiveness of immunotherapy in the overall population. Researchers want to study whether enhancing the activation ability of T cells by supplementing НАД+ levels can enhance the effect of T cell-based immunotherapy. At the same time, in the anti-CD19 CAR-T therapy model and anti-PD-1 immune checkpoint inhibitor therapy model, it was verified that supplementation of НАД+ significantly enhanced the tumor-killing effect of T cells. The researchers found that in the anti-CD19 CAR-T treatment model, almost all mice in the CAR-T treatment group supplemented with НАД+ achieved tumor clearance, while the CAR-T treatment group without НАД+ supplemented only about 20 % Of mice achieved tumor clearance. Consistent with this, in the anti-PD-1 immune checkpoint inhibitor treatment model, B16F10 tumors are relatively tolerant to anti-PD-1 treatment, and the inhibitory effect is not significant. However, the growth of B16F10 tumors in the anti-PD-1 and НАД+ treatment group could be significantly inhibited. Based on this, НАД+ supplementation can enhance the anti-tumor effect of T cell-based immunotherapy. 4.How to supplement НАД+ The НАД+ molecule is large and cannot be directly absorbed and utilized by the human body. The НАД+ directly ingested orally is mainly hydrolyzed by brush border cells in the small intestine. In terms of thinking, there is indeed another way to supplement НАД+, which is to find a way to supplement a certain substance so that it can synthesize НАД+ autonomously in the human body. There are three ways to synthesize НАД+ in the human body: Preiss-Handler pathway, de novo synthesis pathway and salvage synthesis pathway. Although the three ways can synthesize НАД+, there is also a primary and secondary distinction. Among them, the НАД+ produced by the first two synthetic pathways only accounts for about 15% of the total human НАД+, and the remaining 85% is achieved through the way of remedial synthesis. In other words, the salvage synthesis pathway is the key to the human body to supplement НАД+. Among the precursors of НАД+, nicotinamide (NAM), НМН and nicotinamide ribose (NR) all synthesize НАД+ through a salvage synthesis pathway, so these three substances have become the body's choice for supplementing НАД+. Although NR itself has no side effects, in the process of НАД+ synthesis, most of it is not directly converted into НМН, but needs to be digested into NAM first, and then participate in the synthesis of НМН, which still cannot escape the limitation of rate-limiting enzymes. Therefore, the ability to supplement НАД+ through oral administration of NR is also limited . As a precursor for supplementing НАД+, НМН not only bypasses the restriction of rate-limiting enzymes, but is also absorbed very quickly in the body and can be directly converted into НАД+. Therefore, it can be used as a direct, rapid and effective method to supplement НАД+. Expert Reviews: Xu Chenqi (Excellence and Innovation Center of Molecular Cell Science, Chinese Academy of Sciences, Immunology Research Expert) Cancer treatment is a problem in the world. The development of immunotherapy has made up for the limitations of traditional cancer treatment and expanded the treatment methods of doctors. Cancer immunotherapy can be divided into immune checkpoint blocking therapy, engineered T cell therapy, tumor vaccine, etc. These treatment methods have played a certain role in the clinical treatment of cancer. At the same time, this also makes the current focus of immunotherapy research on how to further enhance the effect of immunotherapy and expand the beneficiaries of immunotherapy.
Добавяне на НМН за защита на остеобластите от възпаление, предизвикано от LPS
Introduction It has been reported that infection with Gram-negative bacteria can disrupt the osteogenic differentiation. Notably, nicotinamide mononucleotide (НМН) protects against osteogenesis from inflammation caused by Gram-negative bacterial infections possibly via regulating the Wnt/β-catenin signaling pathway. About osteogenic differentiation Osteogenic differentiation refers to the formation process of osteoblasts from bone marrow mesenchymal stem/stromal (a.k.a. skeletal stem) cells and bone progenitor cells, which is a key event in bone formation during development, fracture repair, and tissue maintenance. Abnormalities in the process of osteogenic differentiation may disrupt physiological bone homeostasis, which is strongly associated with a variety of bone-related diseases such as osteoporosis, bone tumors, and osteoarthritis, making negative impacts upon fracture healing and repair of bone tissue defects. LPS-induced suppression of osteogenesis Lipopolysaccharide (LPS) is a component of the cell wall in Gram-negative bacteria, which is intensively applied to mimic Gram-negative bacterial infections in cell and animal models. LPS can hamper osteogenic differentiation of pre-osteoblasts MC3T3-E1 by diminishing the expression of mRNA markers (Alp1, Bglap, Runx2, and Sp7), ALP activity, and mineralization. Partial protection of НМН against the LPS-induced suppression of osteogenesis LPS-induced inhibition of osteogenic differentiation in MC3T3-E1 cells is partially offset by 1 mM of НМН. Concretely, the mRNA levels of Alp1, Bglap, and Sp7 in cells co-treated with НМН and LPS are relatively higher than those in cells treated solely with LPS. Furthermore, ALP activity and mineralization repressed by LPS are restored in the presence of НМН (1 mM). Potential involvement of the Wnt/β-catenin signaling pathway in НМН's effect on osteogenesis Wnt/β-catenin signaling pathway has been attested to play a vital role in osteogenesis by promoting bone formation and inhibiting bone resorption. In cells treated with LPS, β-catenin is localized in the cytoplasm rather than the nucleus. Following НМН treatment, β-catenin is translocated to the nucleus, similar to what occurred in response to the treatment of osteogenic induction medium (OIM). Meanwhile, the fluorescence intensity of β-catenin is restored upon НМН treatment. Conclusion НМН has a protective role against LPS-induced osteogenesis disruption, which is potentially achieved by the Wnt/β-catenin signaling pathway. НМН may function as a viable therapeutic strategy to preserve bone homeostasis in elderly and immunocompromised patients. Reference Kang I, Koo M, Jun JH, Lee J. Effect of nicotinamide mononucleotide on osteogenesis in MC3T3-E1 cells against inflammation-induced by lipopolysaccharide. Clin Exp Reprod Med. Published online April 11, 2024. doi:10.5653/cerm.2023.06744 BONTAC НМН BONTAC is the pioneer of НМН industry and the first manufacturer to launch НМН mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BOMNTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
Отключване на силата на добавките за стимулиране на метаболизма: Ръководство от BONTAC
Unlocking the Power of Metabolism-Boosting Supplements: A Guide by BONTAC In the realm of health and wellness, the demand for high-quality metabolism-boosting supplements is steadily rising. At BONTAC, we understand the importance of metabolism-boosting supplements in optimizing cellular function and overall well-being. As a leader in the industry of metabolism, we are committed to providing exceptional products that meet the evolving needs of our customers. At BONTAC, we possess a profound comprehension of the significance of metabolism-boosting supplements in optimizing bodily functions. As pioneers in this industry, we remain steadfast in our commitment to delivering unparalleled products that cater to the dynamic and evolving requirements of our esteemed clientele. The Science Behind metabolism-boosting Supplements When it comes to metabolism-boosting supplements, it's crucial to grasp the intricate workings of metabolism and its profound impact on our health. At BONTAC, we harness the power of cutting-edge technology to develop metabolism-boosting supplements that target cellular rejuvenation and vitality. Our products are meticulously crafted to support optimal metabolism-boosting function and promote overall wellness. Benefits of BONTAC metabolism-boosting Supplements At BONTAC, we take pride in offering a range of excellent metabolism-boosting supplements that are designed to meet the unique needs of our customers. One of our flagship products is our НМН Powder, a premium supplement that enhances cellular vitality and supports metabolism-boosting processes. Additionally, our НАД+ supplements play a pivotal role in maintaining optimal metabolism-boosting function and promoting overall health. Technical Support and Innovation Our team at BONTAC is dedicated to providing top-notch technical support to ensure that our customers receive the best possible guidance and assistance. We are committed to staying at the forefront of technological innovation in the field of metabolism-boosting supplements, continuously seeking new ways to enhance our product offerings and improve customer satisfaction. Business Coverage and Product Characteristics With a strong focus on technical innovation and product excellence, BONTAC has established a wide-reaching business coverage that spans various industries, including health, beauty, and biomedicine. Our products are known for their exceptional quality, purity, and effectiveness, making them a preferred choice for customers around the world. Conclusion In conclusion, at BONTAC, we are dedicated to revolutionizing the world of metabolism-boosting supplements through our commitment to excellence, technical innovation, and customer satisfaction. Our range of premium products, backed by top-tier technical support, are designed to help you achieve optimal metabolism-boosting function and lead a healthier, more vibrant life. Join us on this journey towards better health and vitality with BONTAC's exceptional metabolism-boosting supplements.